The skin is the most common target of graft-versus-host disease (GVHD), a frequent complication that occurs after a transplant using donor cells. Although most skin changes after transplant are mild or moderate, more severe skin problems are possible.

Chronic graft-versus-host disease (GVHD) can affect the skin and underlying tissue. It can also affect the mouth and genitals. Therapies vary depending on the type of skin GVHD a patient is experiencing. People with skin GVHD need to be cautious in the sun and monitor themselves closely for signs of skin cancer.